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Comparison of Kasugamycin, Streptomycin, and Oxytetracycline in Plant Disease Control

May 31, 2025

Kasugamycin, Streptomycin, and Oxytetracycline are commonly used antibiotics for bacterial plant diseases. This guide compares their strengths, weaknesses, spectrum of activity, and resistance risk to help farmers choose the right product.


1. Overview of Common Antibiotics for Plant Bacteria

In agricultural disease control, three main bio-antibiotic active ingredients are widely used to treat bacterial infections:

Active Ingredient

Group

Origin

Kasugamycin

Aminoglycoside

Biological (Streptomyces kasugaensis)

Streptomycin

Aminoglycoside

Biological (Streptomyces griseus)

Oxytetracycline

Tetracycline

Biological (Streptomyces rimosus)

All three are microbial-based antibiotics that inhibit bacterial activity, but they differ in mode of action, coverage, and safety.


2. Comparison Table: Kasugamycin vs Streptomycin vs Oxytetracycline

Criteria

Kasugamycin

Streptomycin

Oxytetracycline

Mode of action

Inhibits protein synthesis (30S)

Inhibits protein synthesis (30S)

Inhibits protein synthesis (50S)

Target spectrum

Gram-negative & Gram-positive bacteria

Mostly Gram-negative

Both Gram-negative & positive

Efficacy

Very strong

Good

⚠️ Moderate

Resistance risk

Low with rotation

High if overused

High if overused

Formulations

SP, SL

SP, SL

WP, SL

Crop safety

High

Moderate

⚠️ Risk of leaf burn

Suitable for fruits/vegetables

Very suitable

Acceptable

⚠️ Use with caution

Fits clean/GAP production

Easy to qualify

Limited if overused

Longer residue period


3. Pros and Cons of Each Antibiotic

🌱 Kasugamycin

KASUGAMYCIN | 6980-18-3

Pros:

  • Low resistance risk
  • Excellent for both prevention and treatment
  • Ideal for clean and sustainable agriculture

Cons:

  • Higher cost
  • Works best when sprayed early – less effective on severe infections

🌾 Streptomycin

Pros:

  • Fast-acting on common bacterial diseases (e.g., bacterial blight)
  • Affordable and widely available

Cons:

  • High resistance potential if overused
  • Use restricted in some countries due to residue concerns

🍅 Oxytetracycline

Pros:

  • Works well when combined with copper fungicides
  • Useful for some soft rot and leaf burn issues

Cons:

  • May cause leaf burn at high concentrations
  • Not suitable for GAP/organic farming due to residue persistence

4. Which Antibiotic to Choose for Bacterial Plant Diseases?

Scenario

Recommended Product

Early-stage, mild infection

Kasugamycin – effective, safe

Rice blight – fast action needed

Streptomycin + Copper (alternate)

Vegetables and fruits under GAP/clean farming

Kasugamycin is the top choice

Low-budget situation

⚠️ Oxytetracycline (combine for safety)


5. Conclusion

Kasugamycin stands out as the safest and most sustainable option among bacterial-control antibiotics, offering strong efficacy with a low risk of resistance. Though more expensive, it’s well-suited for export-quality and clean farming systems.

👉 Expert tip: Rotate antibiotic products wisely and avoid overusing Streptomycin or Oxytetracycline to prevent resistance and maintain long-term effectiveness.

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